Neurobiology of Disease Small Heat Shock Proteins Induce a Cerebral Inflammatory Reaction
نویسندگان
چکیده
Ilona B. Bruinsma,1,2 Mieke de Jager,1,2 Anna Carrano,5 Alexandra A. M. Versleijen,1,2 Robert Veerhuis,6 Wilbert Boelens,3 Annemieke J. M. Rozemuller,5 Robert M. W. de Waal,4 and Marcel M. Verbeek1,2 Departments of 1Neurology and Alzheimer Centre, 2Laboratory Medicine, 3Biomolecular Chemistry and Nijmegen Centre for Molecular Life Sciences, and 4Pathology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands, and Departments of 5Neuropathology and 6Clinical Chemistry, Psychiatry and Alzheimer Center, VU University Medical Center, 1081 BT Amsterdam, the Netherlands
منابع مشابه
Small heat shock proteins induce a cerebral inflammatory reaction.
More than 80% of Alzheimer's disease (AD) patients have some degree of cerebral amyloid angiopathy (CAA). In addition to arteries and veins, capillaries can also be affected. Capillary CAA (capCAA), rather than CAA in larger vessels, is associated with flame-like amyloid-beta (Aβ) deposits that may extend beyond the vessel wall and radiate into the neuropil, a phenomenon also known as "dyshoric...
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